Clinical Associations between Serial Electrocardiography Measurements and Sudden Cardiac Death in Patients with End-Stage Renal Disease Undergoing Hemodialysis
- 주제(키워드) critical care , hemodialysis , death , sudden , cardiac , electrocardiography , kidney failure , arrhythmias
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Lee, Hyun Jin] Yonsei Univ, Severance Hosp, Dept Internal Med, Coll Med, Seoul 03722, South Korea; [Choe, A. Reum; Ryu, Dong Ryeol] Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul 07985, South Korea; [Lee, HaeJu] Seoul Natl Univ Hosp, Dept Thorac & Cardiovasc Surg, Seoul 03080, South Korea; [Kang, Ea Wha] Ilsan Hosp, Dept Internal Med, Natl Hlth Insurance Serv, Div Nephrol, Goyang 10444, South Korea; [Park, Jung Tak] Yonsei Univ, Inst Kidney Dis Res, Dept Internal Med, Coll Med, Seoul 03722, South Korea; [Lee, Su Hwan] Yonsei Univ, Severance Hosp, Div Pulm & Crit Care Med, Dept Internal Med,Coll Med, Seoul 03722, South Korea; [Park, Junbeom] Ewha Womans Univ, Div Cardiol, Dept Internal Med, Coll Med, Seoul 07985, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181592
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/jcm10091933
초록/요약
The rate of sudden cardiac death (SCD) for hemodialysis (HD) patients is significantly higher than that observed in the general population and have the highest risk for arrhythmogenic death. In this multi-center study, patients starting hemodialysis in each hospital were enrolled; they underwent regular check-ups in an open-patient clinic. We examined serial electrocardiography (ECG) data in patients undergoing HD and determined their associations with the occurrence of SCD. Of 678 enrolled subjects who underwent serial ECG before and after hemodialysis, 291 died and 39 developed SCD. In all subjects, the QT peak-to-end (QTpe) interval at all leads and QRS duration were shortened after hemodialysis. The SCD group showed a significant change in the QTpe interval of the inferior, anterior, and lateral leads before and after hemodialysis compared with the survivor group (p < 0.001). In the pre-hemodialysis ECG, SCD patients had significantly longer QTpe intervals in all leads (p < 0.001) and a longer QRS duration (92.6 +/- 14.0 vs. 100.6 +/- 14.9 ms, p = 0.015) than survivors. In conclusion, patients with a longer QTpe interval before hemodialysis and large changes in ECG parameters after hemodialysis might be at a higher risk of SCD. Therefore, changes in the ECG before and after hemodialysis could help to predict SCD.
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