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Risk of Absence of Measles Antibody in Healthcare Personnel and Efficacy of Booster Vaccination

  • 주제(키워드) measles , health personnel , vaccination
  • 주제(기타) Immunology
  • 주제(기타) Medicine, Research & Experimental
  • 설명문(일반) [Kim, Chung-Jong; Jun, Kang-Il] Ewha Womans Univ, Dept Internal Med, Seoul Hosp, Seoul 07804, South Korea; [Kim, Chung-Jong; Bae, Ji-Yun; Jun, Kang-Il; Chung, Hae-Sun; Lee, Miae; Choi, Hee-Jung] Ewha Educ & Res Ctr Infect, Seoul 07985, South Korea; [Bae, Ji-Yun; Choi, Hee-Jung] Ewha Womans Univ, Dept Internal Med, Mokdong Hosp, Seoul 07985, South Korea; [Chung, Hae-Sun] Ewha Womans Univ, Dept Lab Med, Seoul Hosp, Seoul 07804, South Korea; [Kim, Aeyeon; Kim, Jihee] Ewha Womans Univ, Off Infect Control, Seoul Hosp, Seoul 07804, South Korea; [Son, Hee-Jung] Ewha Womans Univ, Off Infect Control, Mokdong Hosp, Seoul 07985, South Korea; [Lee, Miae] Ewha Womans Univ, Dept Lab Med, Mokdong Hosp, Seoul 07985, South Korea
  • 등재 SCIE, SCOPUS
  • 발행기관 MDPI
  • 발행년도 2021
  • 총서유형 Journal
  • URI http://www.dcollection.net/handler/ewha/000000181605
  • 본문언어 영어
  • Published As http://dx.doi.org/10.3390/vaccines9050501

초록/요약

We aimed to identify the presence of the measles IgG antibody (mIgG-Ab) in healthcare personnel and finding out who needs the measles vaccination. The history of measles vaccination was obtained from the national vaccine registry. A baseline mIgG-Ab test was performed, and the measles vaccine was administered to participants who tested negative or equivocal for mIgG-Abs. During the study, 2885 (87.3%) of the 3303 employees were tested for measles serostatus. The baseline seropositivity rate for mIgG-Abs was 91.9%. Among the 234 seronegative cases, 82.9% were born after 1985. The seroprevalence rate was lower in those who received the measles-mumps-rubella (MMR) vaccine >10 years before the testing time, especially if they were born after 1985 and if there was only one previous record of vaccination. Among the 234 seronegative cases, MMR vaccination was administered in 174 cases, of which serostatus was evaluated in 146 cases. After the first dose, positive seroconversion was achieved in 126 participants (86.3%). After a second dose, 15 achieved (75.0%) positive seroconversion. In healthcare personnel born after the period when measles incidence significantly decreased, it may be necessary to reassess their immune status for measles if more than 10 years have elapsed since the last vaccination.

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