Characteristics, Location, and Clinical Outcomes of Gastrointestinal Bleeding in Patients Taking New Oral Anticoagulants Compared to Vitamin K Antagonists
- 주제(키워드) gastrointestinal bleeding , new oral anticoagulants , vitamin K antagonist , rebleeding
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Choe, A. Reum; Moon, Chang Mo; Tae, Chung Hyun] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul 07985, South Korea; [Moon, Chang Mo] Ewha Womans Univ, Coll Med, Inflammat Canc Microenvironm Res Ctr, Seoul 07804, South Korea; [Chun, Jaeyoung] Seoul Natl Univ, Liver Res Inst, Dept Internal Med, Coll Med, Seoul 03080, South Korea; [Chun, Jaeyoung] Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul 06273, South Korea; [Bang, Ki Bae] Dankook Univ, Dept Internal Med, Coll Med, Cheonan 31116, South Korea; [Lee, Yoo Jin] Keimyung Univ, Dept Internal Med, Sch Med, Daegu 42601, South Korea; [Lee, Hyun Seok] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea; [Jung, Yunho] Soonchunhyang Univ, Dept Internal Med, Coll Med, Cheonan 31151, South Korea; [Park, Sung Chul] Kangwon Natl Univ, Dept Internal Med, Sch Med, Chunchon 24289, South Korea; [Koo, Hoon Sup] Konyang Univ, Dept Internal Med, Coll Med, Daejeon 35365, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000181643
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/jcm10122693
초록/요약
New oral anticoagulants (NOACs) are commonly used in clinical practice as alternatives to vitamin K antagonists (VKA). However, the etiology, clinical course, and risk of gastrointestinal (GI) bleeding remain unclear. We aimed to evaluate the clinical characteristics and location of acute GI bleeding associated with NOACs and its severity and outcomes compared to VKA. This retrospective multicenter study included 381 subjects on anticoagulants who underwent appropriate diagnostic examination due to GI bleeding. Regarding the characteristics of acute GI bleeding, the proportion of vascular lesions was significantly lower in the NOACs group than that in the VKA group. Small bowel bleeding occurred less commonly in the NOACs group, but the difference did not reach statistical significance. Regarding severity and clinical outcomes, patients on NOACs received significantly smaller volumes of transfused blood products and had shorter ICU stays than those on VKA. Moreover, the need for surgery and the risk of rebleeding in the NOACs group were significantly lower than those in the VKA group. Patients on NOACs have better clinical outcomes in terms of severity of acute GI bleeding or rebleeding than patients on VKA. Patients on NOACs demonstrate different characteristics and location of acute GI bleeding than those on VKA.
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