Protective effect of controlled blood pressure on risk of dementia in low-risk, grade 1 hypertension
- 주제(키워드) Alzheimer's disease , blood pressure , dementia , grade 1 hypertension , vascular dementia
- 주제(기타) Peripheral Vascular Disease
- 설명문(일반) [Lee, Chan Joo; Park, Sungha] Yonsei Univ, Coll Med, Div Cardiol, Severance Cardiovasc Hosp, 50-1 Yonsei Ro, Seoul 03722, South Korea; [Lee, Chan Joo; Park, Sungha] Yonsei Univ, Coll Med, Integrat Res Ctr Cerebrovasc & Cardiovasc Dis, Seoul, South Korea; [Hwang, Jinseub; Kang, Chae Young] Daegu Univ, Dept Stat & Comp Sci, Gyongsan, South Korea; [Kim, Hyeon-Chang; Kim, Changsoo] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; [Ryu, Dong-Ryeol] Ewha Womans Univ, Div Nephrol, Dept Internal Med, Sch Med, Seoul, South Korea; [Ihm, Sang-Hyun] Catholic Univ Korea, Div Cardiol, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, Yong-Jin] Seoul Natl Univ, Div Cardiol, Coll Med, Seoul, South Korea; [Shin, Jin-Ho] Hanyang Univ, Div Cardiol, Dept Internal Med, Coll Med, Seoul, South Korea; [Pyun, Wook Bum] Ewha Womans Univ, Dept Internal Med, Cardiovasc Ctr, Sch Med, Seoul, South Korea; [Kim, Changsoo] Yonsei Univ, Inst Human Complex & Syst Sci, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 LIPPINCOTT WILLIAMS & WILKINS
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182270
- 본문언어 영어
- Published As http://dx.doi.org/10.1097/HJH.0000000000002820
초록/요약
Objective: High blood pressure (BP) increases the risk of dementia; however, few studies have reported on the risk of dementia in patients with low-risk, early-grade hypertension. We investigated the protective effect of controlled BP on risk of dementia in treated, low-risk, grade 1 hypertensive patients from the entire National Health Insurance Service National Health Examinee cohort. Methods: We selected grade 1 hypertension (140-159/90-99 mmHg) patients with low risk, diagnosed in 2005-2006. All patients (N = 128 665) were classified into controlled (average BP < 140/90 mmHg during the follow-up) and uncontrolled (average BP >= 140/90 mmHg) BP groups and followed up until 2015. The risk of dementia was estimated using Cox proportional hazard model after adjustments for propensity score. Results: Average BP was 131/81 mmHg in the controlled group (N = 49 408) and 144/87 mmHg in the uncontrolled group (N = 99 257). Overall dementia incidence rates in controlled and uncontrolled groups were 4.9 and 8.1 per 1000 person-year, respectively. The controlled group showed lower risk of overall dementia, Alzheimer's disease, and vascular dementia than the uncontrolled group. The controlled group had a low risk of vascular dementia at all ages, especially in the younger group (age <60). The optimal BP level associated with the lowest risk of dementia was 130 to less than 140 mmHg for SBP and 70 to less than 80 mmHg for DBP. Conclusion: We concluded that among even low-risk and grade 1 hypertension patients, controlled BP significantly reduced the risk of dementia, including Alzheimer's disease and vascular dementia.
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