Myostatin/Appendicular Skeletal Muscle Mass (ASM) Ratio, Not Myostatin, Is Associated with Low Handgrip Strength in Community-Dwelling Older Women
- 주제(키워드) myostatin , skeletal muscle mass , elderly
- 주제(기타) Environmental Sciences
- 주제(기타) Public, Environmental & Occupational Health
- 설명문(일반) [Choi, Soo Jeong; Yu, Byung Chul; Park, Moo Yong; Kim, Jin Kuk; Hwang, Seung Duk] Soonchunhyang Univ, Dept Internal Med, Div Nephrol, Coll Med, Bucheon 14584, South Korea; [Lee, Min Sung; Kang, Duk-Hee] Ewha Womans Univ, Dept Internal Med, Div Nephrol, Coll Med, Seoul 07804, South Korea; [Ko, Gang Jee] Korea Univ, Dept Internal Med, Div Nephrol, Coll Med, Seoul 08308, South Korea; [Lim, Hee-Sook] Yeonsung Univ, Dept Food Sci & Nutr, Anyang 14011, South Korea; [Kim, Chul-Hee] Soonchunhyang Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, Bucheon 14854, South Korea; [Kim, Jun Chul] CHA Univ, Dept Internal Med, Div Nephrol, Sch Med, Gumi 39295, South Korea; [Won, Chang Won] Kyung Hee Univ, Dept Family Med, Sch Med, Seoul 02447, South Korea; [An, Won Suk] Dong A Univ, Div Nephrol, Dept Internal Med, Coll Med, Busan 49201, South Korea
- 등재 SCIE, SSCI, SCOPUS
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182319
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/ijerph18147344
초록/요약
Background/Aims: Elevated levels of serum myostatin have been proposed as a biomarker for sarcopenia. Recent studies have shown that elevated level of serum myostatin was associated with physical fitness and performance. This study aimed to examine the significance of myostatin in the association between muscle mass and physical performance in the elderly. Methods: This cross-sectional study is based on the Korean Frailty and Aging Cohort study involving 1053 people aged 70 years or over. Anthropometric, physical performance, and laboratory data were collected. Results: The mean age of the participants was 75.8 years, and 50.7% of them were female. Serum myostatin levels in men (3.7 +/- 1.2 vs. 3.2 +/- 1.1 ng/mL, p < 0.001) were higher compared with that in women. Serum myostatin level was associated with appendicular skeletal muscle mass (ASM) index and eGFR by cystatin C. Serum myostatin/ASM ratio was associated with handgrip strength in women. Conclusion: Higher serum myostatin levels were related with higher muscle mass and better physical performances in the elderly. Serum myostatin/ASM ratio may be a predictor for physical performance rather than myostatin.
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