Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Kim, Hwi Young; Kim, Tae Hun; Yoo, Kwon] Ewha Womans Univ, Dept Internal Med, Coll Med, 1071 Anyangcheon Ro, Seoul 07985, South Korea; [Baik, Su Jung; Lee, Byoung Kwon] Gangnam Severance Hosp, Hlth Promot Ctr, Healthcare Res Team, Seoul, South Korea; [Lee, Hye Ah] Ewha Womans Univ, Clin Trial Ctr, Med Ctr, Seoul, South Korea; [Lee, Byoung Kwon] Yonsei Univ Hlth Syst, Gangnam Severance Hosp Cardiovasc Ctr, Div Cardiol, Seoul, South Korea; [Lee, Hye Sun] Yonsei Univ, Biostat Collaborat Unit, Med Res Ctr, Coll Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 NATURE RESEARCH
- 발행년도 2020
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182437
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/s41598-020-74659-9
- PubMed https://pubmed.ncbi.nlm.nih.gov/33060775
초록/요약
The relationship between changes in body components and the risk of nonalcoholic fatty liver disease (NAFLD) is not fully understood. We investigated the effects of body components and subsequent changes on incident NAFLD at follow-up ultrasound scanning in a longitudinal cohort. We included 9967 participants without NAFLD at baseline who underwent serial health examinations. Sex-specific, weight-adjusted skeletal muscle index (SMI_Wt) was used. Mean follow-up duration was 48.5 +/- 33.5 months. NAFLD developed in 2395 participants (24.0%). Body composition was measured using bioelectrical impedance analysis. The following baseline body components were significantly associated with incident NAFLD: the lowest and middle SMI_Wt tertiles in the normal-weight group (adjusted hazard ratio [aHR]=2.20 and 1.54, respectively), and fat percentage in the normal-weight (aHR=1.12), overweight (aHR=1.05), and obese groups (aHR=1.03) (all P<0.05). Among 5,033 participants who underwent<greater than or equal to>3 health examinations, SMI_Wt increase between the first and second examinations was an independent protective factor against incident NAFLD in non-obese groups (P<0.05). Increased fat percentage was an independent risk factor for incident NAFLD in all weight categories (P<0.05). High fat mass at baseline may be a better predictor of incident NAFLD than muscle mass. Reciprocal changes in fat and muscle mass during the first year of follow-up predicted incident NAFLD in non-obese groups.
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