Characteristics of Specialist-Diagnosed Asthma-COPD Overlap in Severe Asthma: Observations from the Korean Severe Asthma Registry (KoSAR)
- 주제(키워드) asthma-COPD overlap , registry , severe asthma
- 주제(기타) Allergy
- 주제(기타) Immunology
- 설명문(일반) [Lee, Hyun; Kim, Sang-Heon; Yoon, Ho Joo] Hanyang Univ, Dept Internal Med, Coll Med, 222 Wangsimni Ro, Seoul 04763, South Korea; [Kim, Byung-Keun] Korea Univ, Dept Internal Med, Med Ctr, Anam Hosp, Seoul, South Korea; [Lee, Youngsoo; Park, Hae-Sim] Ajou Univ, Dept Allergy & Clin Immunol, Sch Med, Suwon, South Korea; [Lee, Hwa Young; Rhee, Chin Kook] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Pulm Allergy & Crit Care Me, Seoul, South Korea; [Ban, Ga-Young] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Pulm Allergy & Crit Care Med, Coll Med, Seoul, South Korea; [Kim, Min-Hye] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Kim, Joo-Hee] Hallym Univ, Dept Internal Med, Coll Med, Anyang, South Korea; [Kwon, Jae-Woo] Kangwon Natl Univ, Dept Internal Med, Sch Med, Chunchon, South Korea; [Park, So-Young; Yoo, Kwang Ha] Konkuk Univ, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Sch Med, Seoul, South Korea; [Jung, Jae-Woo] Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Park, So Young] Eulji Univ, Dept Internal Med, Sch Med, Seoul, South Korea; [Park, Chan Sun] Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; [Lee, Taehoon] Univ Ulsan, Ulsan Univ Hosp, Dept Internal Med, Coll Med, Ulsan, South Korea; [Lee, Jae-Hyun] Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, So Ri] Chonbuk Natl Univ, Dept Internal Med, Div Resp Med & Allergy, Med Sch, Jeonju, South Korea; [Park, Jong-Sook; Jang, An-Soo; Park, Choon-Sik] Soonchunhyang Univ, Dept Internal Med, Coll Med, Bucheon, South Korea; [Park, Heung-Woo; Cho, Sang-Heon] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Oh, Yeon-Mok; Cho, You Sook] Univ Ulsan, Dept Internal Med, Coll Med, Seoul, South Korea; [Koh, Young-Il] Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; [Lee, Byung-Jae] Sungkyunkwan Univ, Dept Med, Sch Med, Seoul, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 WILEY
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000182496
- 본문언어 영어
- Published As http://dx.doi.org/10.1111/all.14483
- PubMed https://pubmed.ncbi.nlm.nih.gov/33411398
초록/요약
Background While the clinical characteristics and outcomes of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) have been frequently compared with those of COPD or asthma, the prevalence and features of ACO in patients with severe asthma are unclear. Objectives Evaluation of the prevalence and clinical features of ACO using the Korean severe asthma registry. Methods At the time of registration, ACO was determined in patients with severe asthma by attending specialists. Patients were classified into ACO and non-ACO groups, and the demographic and clinical characteristics of these two groups were compared. Results Of 482 patients with severe asthma, 23.7% had ACO. Patients in the ACO group were more likely to be male (P < .001), older (P < .001), and ex- or current smokers (P < .001) compared with those in the non-ACO group. Patients in the ACO group had lower mean forced expiratory volume in 1 second (P < .001) and blood eosinophil percentage (P = .006), but higher blood neutrophil percentage (P = .027) than those in the non-ACO group. The ACO group used more inhaled long-acting muscarinic antagonist (P < .001), methylxanthine (P = .001), or sustained systemic corticosteroid (P = .002). In addition, unscheduled emergency department visits due to exacerbation were more frequent in the ACO group (P = .006). Conclusion Among patients with severe asthma, those with ACO were older, predominantly male, and were more likely to have a smoking history than those with asthma only. Patients with ACO used more systemic corticosteroid and had more frequent exacerbations related to emergency department visits than those with severe asthma only.
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