6.5-GHz Brain Stimulation System Using Enhanced Probe Focusing and Switch-Driven Modulation
- 주제(키워드) Probes , Brain stimulation , Voltage-controlled oscillators , Microwave oscillators , Microwave theory and techniques , Microwave circuits , Transistors , Brain stimulation system , microwave circuits , neural probe , neuromodulation , probes , stimulation system
- 주제(기타) Engineering, Electrical & Electronic
- 설명문(일반) [Oh, Seongwoog; Oh, Jungsuek] Seoul Natl Univ, Inst New Media & Commun INMC, Dept Elect & Comp Engn ECE, Seoul 151742, South Korea; [Jung, Dahee] Korea Inst Sci & Technol, Ctr Funct Connect, Seoul 02792, South Korea; [Seo, Taeyoon] Samsung Elect Co Ltd, Suwon 16677, South Korea; [Huh, Yeowool] Catholic Kwandong Univ, Translat Brain Res Ctr, Int St Marys Hosp, Incheon 21431, South Korea; [Huh, Yeowool] Catholic Kwandong Univ, Dept Med, Coll Med, Gangneung Si 25601, South Korea; [Cho, Jeiwon] Ewha Womans Univ, Scranton Coll, Dept Brain & Cognit Sci, Seoul 03760, South Korea
- 등재 SCIE, SCOPUS
- 발행기관 IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183507
- 본문언어 영어
- Published As http://dx.doi.org/10.1109/TMTT.2021.3075726
초록/요약
This article, for the first time, presents the design, fabrication, and measurement results of a novel microwave brain stimulation system enabling efficient probe focusing of rectangular-pulse enveloped 6.5-GHz waves. While the conventional ON/OFF stimulation systems in literature employ low frequencies below 0.5 GHz, the proposed system employs 6.5 GHz that can achieve more spatial energy focusing and a moderate level of energy penetration depth. In the proposed system, the ON/OFF modulated microwave signal is generated by a single chip consisting of a voltage-controlled oscillator (VCO) and power amplifier (PA). The VCO is driven by a switch at the current source to generate modulated signals with over 20-dB isolation between the high and low states. The probe with a center-opened aperture surrounded by a symmetric loading enables low power reflection toward the brain and focuses the field in the square-shaped aperture of 1-mm(2) area. Finally, it is demonstrated that the 20-min stimulation of an in vivo mouse brain using microwave signals with 1-Hz repetitive pulse envelopes and 1% duty cycle enables the normalized firing rate to reach up to 0.2 while the normalized firing rate stays just within +/- 0.05 under no stimulation. This suggests that the proposed brain stimulation system can achieve a dramatic change in the activity of individual hippocampal neurons.
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