Risk of colorectal cancer in patients with positive results of fecal immunochemical test performed within 5 years since the last colonoscopy
- 주제(키워드) Fecal immunochemical test , Colorectal neoplasms , Colonoscopy
- 주제(기타) Medicine, General & Internal
- 설명문(일반) [Jung, Yoon Suk] Sungkyunkwan Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Seoul, South Korea; [Lee, Jinhee] Ajou Univ, Dept Endocrinol & Metab, Sch Med, Suwon, South Korea; [Moon, Chang Mo] Ewha Womans Univ, Coll Med, Dept Internal Med, 1071 Anyangcheon Ro, Seoul 07985, South Korea; [Moon, Chang Mo] Ewha Womans Univ, Coll Med, Inflammat Canc Microenvironm Res Ctr, Seoul, South Korea
- 등재 SCIE, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN ASSOC INTERNAL MEDICINE
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183613
- 본문언어 영어
- Published As http://dx.doi.org/10.3904/kjim.2020.525
- PubMed https://pubmed.ncbi.nlm.nih.gov/34134468
초록/요약
Background/Aims: Annual fecal immunochemical tests (FITs) are often repeated within the recommended colonoscopy surveillance intervals. However, it remains unclear whether interval FITs are useful. To answer this question, we assessed the risk of colorectal cancer (CRC) according to the interval from the last colonoscopy to an FIT. Methods: Using the Korean National Cancer Screening Program database, we collected data on patients who underwent FITs in 2011. Patients with positive FIT results were classified into three groups according to their previous colonoscopy interval: 0.5 to 5 years (group 1), 5 to 10 years (group 2), and >= 10 years or no colonoscopy (group 3). CRC incidence was defined as CRC diagnosed within 1 year after an FIT. Results: Among 177,660 patients with positive FIT results, the incidence of CRC in groups 1, 2, and 3 was 0.72% (n = 214/29,575), 1.28% (n = 116/9,083), and 3.88% (n = 5,387/139,002), respectively. The age-and sex-adjusted risk for CRC was higher in groups 2 (odds ratio [OR], 1.79; 95% confidence interval [CI], 1.43 to 2.25) and 3 (OR, 5.56; 95% CI, 4.85 to 6.38) than in group 1. Among patients who did and did not undergo a polypectomy during the previous colonoscopy, those in group 2 had a higher rate of CRC than those in group 1 (without polypectomy: 1.15% vs. 0.63%; OR, 1.79; 95% CI, 1.37 to 2.34) (with polypectomy: 2.37% vs. 0.93 %; OR, 2.30; 95% CI, 1.44 to 3.69). Conclusion: In patients with positive FIT results who had undergone a colonoscopy within the past 5 years, the risk of CRC is very low, regardless of whether a polypectomy was performed, suggesting that interval FITs are not useful.
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