'Fearful-place' coding in the amygdala-hippocampal network
- 주제(키워드) decision making , fear , predator , place cells , simultaneous recording , spike synchrony , Rat
- 주제(기타) Biology
- 설명문(일반) [Kong, Mi-Seon; Kim, Eun Joo; Kim, Jeansok J.] Univ Washington, Dept Psychol, Seattle, WA USA; [Kong, Mi-Seon; Zweifel, Larry S.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA USA; [Park, Sanggeon; Cho, Jeiwon] Ewha Womans Univ, Scranton Coll, Dept Brain & Cognit Sci, Seoul, South Korea; [Park, Sanggeon; Huh, Yeowool] Catholic Kwandong Univ, Int St Marys Hosp, Inst Biomed Convergence, Incheon, South Korea; [Zweifel, Larry S.] Univ Washington, Dept Pharmacol, Seattle, WA USA; [Huh, Yeowool] Catholic Kwandong Univ, Coll Med, Dept Med Sci, Kangnung, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 eLIFE SCIENCES PUBL LTD
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183681
- 본문언어 영어
- Published As http://dx.doi.org/10.7554/eLife.72040; 10.7554/eLife.72040.sa1; 10.7554/eLife.72040.sa2
- PubMed https://pubmed.ncbi.nlm.nih.gov/34533133
초록/요약
Animals seeking survival needs must be able to assess different locations of threats in their habitat. However, the neural integration of spatial and risk information essential for guiding goal-directed behavior remains poorly understood. Thus, we investigated simultaneous activities of fear-responsive basal amygdala (BA) and place-responsive dorsal hippocampus (dHPC) neurons as rats left the safe nest to search for food in an exposed space and encountered a simulated 'predator.' In this realistic situation, BA cells increased their firing rates and dHPC place cells decreased their spatial stability near the threat. Importantly, only those dHPC cells synchronized with the predator-responsive BA cells remapped significantly as a function of escalating risk location. Moreover, optogenetic stimulation of BA neurons was sufficient to cause spatial avoidance behavior and disrupt place fields. These results suggest a dynamic interaction of BA's fear signalling cells and dHPC's spatial coding cells as animals traverse safe-danger areas of their environment.
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