Association between ADCY9 Gene Polymorphisms and Ritodrine Treatment Outcomes in Patients with Preterm Labor
- 주제(키워드) adenylyl cyclase 9 gene , adverse drug events , preterm labor , ritodrine , single nucleotide polymorphism , time to delivery
- 주제(기타) Pharmacology & Pharmacy
- 설명문(일반) [Lee, Nari; Yoon, Ha-Young; Park, Jin-Young; Yee, Jeong; Gwak, Hye-Sun] Ewha Womans Univ, Coll Pharm, Seoul 03760, South Korea; [Lee, Nari; Yoon, Ha-Young; Park, Jin-Young; Yee, Jeong; Gwak, Hye-Sun] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; [Kim, Young-Ju] Ewha Womans Univ, Sch Med, Dept Obstet & Gynecol, Seoul 07985, South Korea; [Hwang, Han-Sung] Konkuk Univ, Sch Med, Med Ctr, Dept Obstet & Gynecol, Seoul 05030, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 MDPI
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183750
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/pharmaceutics13101653
- PubMed https://pubmed.ncbi.nlm.nih.gov/34683946
초록/요약
The purpose of this study was to investigate the genetic effects of ADCY9 on ritodrine responses in patients with preterm labor. Five single nucleotide polymorphisms (SNPs) of the ADYC9 gene in 163 patients in preterm labor were genotyped: rs879619, rs2601796, rs2531988, rs2531995, and rs2230739. Additionally, rs598961 of the PDE4B gene and rs1042719 of the ADRB2 gene were included for analysis. Patients with CC genotype of ADCY9 rs879619 had a 2.0-fold (95% confidence interval [CI]: 1.3, 3.2) higher hazard of time to delivery than T allele carriers. Patients with combined genotypes of CC in ADCY9 rs879619, AA in PDE4B rs598961, and GC, CC in ADRB2 rs1042719 showed a greater hazard of time to delivery than patients with other combinations (adjusted hazard ratio [AHR] 3.2; 95% CI: 1.7, 6.3), whereas patients carrying the C allele of ADCY9 rs2531995, G allele of PDE4B rs598961, and GG genotype of ADRB2 rs1042719 had a lower hazard of time to delivery than patients carrying other genotypes (AHR 0.4; 95% CI: 0.2, 0.7). Regarding ritodrine-induced adverse drug events (ADEs), height less than 160 cm and CC genotype of ADCY9 rs2531995 showed a greater risk of ADEs. The results of our study suggest that ADCY9 polymorphisms could affect the efficacy and safety of beta(2)-adrenergic agonists.</p>
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