Effect of low protein intake on acute exacerbations in mild to moderate chronic obstructive pulmonary disease: data from the 2007-2012 KNHANES
- 주제(키워드) Chronic obstructive pulmonary disease (COPD) , exacerbation , nutrient , protein , pulmonary function
- 주제(기타) Respiratory System
- 설명문(일반) [Park, Sojung; Lee, Jin Hwa] Ewha Womans Univ, Coll Med, Dept Internal Med, Div Pulm & Crit Care Med, 25 Magokdong Ro 2 Gil, Seoul 07804, South Korea; [Kim, Seo Woo] Dongbu Municipal Hosp, Dept Internal Med, Seoul, South Korea; [Rhee, Chin Kook; Kim, Kyungjoo] Catholic Univ Korea, Seoul St Marys Hosp, Div Pulm Allergy & Crit Care Med, Coll Med,Dept Internal Med, Seoul, South Korea; [Kim, Woo Jin] Kangwon Natl Univ, Sch Med, Dept Internal Med, Chunchon, South Korea; [Kim, Woo Jin] Kangwon Natl Univ, Sch Med, Environm Hlth Ctr, Chunchon, South Korea; [Ha Yoo, Kwang] Konkuk Univ, Sch Med, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Seoul, South Korea; [Lee, Chang Youl] Hallym Univ, Coll Med, Div Pulm Allergy & Crit Care Med, Chuncheon Sacred Heart Hosp,Dept Internal Med, Chunchon, South Korea; [Kim, Deog Kyeom] Seoul Natl Univ, Seoul Metropolitan Govt, Div Pulm & Crit Care Med, Dept Internal Med,Boramae Med Ctr,Coll Med, Seoul, South Korea; [Park, Yong Bum] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Seoul, South Korea; [Jung, Ki-Suck] Hallym Univ, Sacred Heart Hosp, Div Pulm Allergy & Crit Care Med, Coll Med,Dept Internal Med, Anyang, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 AME PUBL CO
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183778
- 본문언어 영어
- Published As http://dx.doi.org/10.21037/jtd-20-3433
- PubMed https://pubmed.ncbi.nlm.nih.gov/34795910
초록/요약
Background: Several researchers have reported that the amount of protein intake is associated with lung function and airflow obstruction. However, few studies have investigated the effect of low protein intake on acute exacerbations of chronic obstructive pulmonary disease. This study aimed to investigate the effect of low protein intake on exacerbations in mild to moderate chronic obstructive pulmonary disease. Methods: We used data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2007 and 2012, linked to the National Health Insurance claims data. The clinical outcomes and the rate of exacerbation were retrospectively compared between the low protein intake group and the non-low protein intake group which was stratified by quartile categories of protein intake in 2,069 patients with mild to moderate chronic obstructive pulmonary disease. Results: The low protein intake group was significantly associated with older age, women, never smoker, low household income, and low education level, compared with the non-low protein intake group. The low protein intake group was significantly associated with increased hospitalization (18.0% vs. 10.5%, P<0.001) and emergency department utilization (1.6 +/- 1.0 vs. 1.1 +/- 0.4, P=0.033) compared with the non-low protein intake group. In multivariate analysis, the low protein intake group was associated with hospitalization (odds ratio 1.46; 95% CI, 1.09-1.96; P=0.012). The multiple linear regression analysis revealed that the amount of protein intake was associated with FVC % predicted (beta=0.048, P<0.001) and FEV1 % predicted (beta=0.022, P=0.015). Conclusions: Low protein intake was associated with an increased risk of exacerbations in mild to moderate chronic obstructive pulmonary disease. The data are available at the KNHANES website (https://knhanes.cdc.go.kr).
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