Aging effects on the diurnal patterns of gut microbial composition in male and female mice
- 주제(키워드) Aging , Diurnal rhythm , Dysbiosis , Gut microbiota , Sex difference
- 주제(기타) Pharmacology & Pharmacy; Physiology
- 설명문(일반) [Kim, Hyun-Jung; Park, Eun-Mi] Ewha Womans Univ, Dept Pharmacol, Coll Med, Seoul 07084, South Korea; [Moon, Chang Mo] Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul 07084, South Korea; [Moon, Chang Mo; Kang, Jihee Lee] Ewha Womans Univ, Inflammat Canc Microenvironm Res Ctr, Coll Med, Seoul 07084, South Korea; [Kang, Jihee Lee] Ewha Womans Univ, Dept Physiol, Coll Med, Seoul 07084, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 gold, Green Published
- 발행기관 KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000183815
- 본문언어 영어
- Published As http://dx.doi.org/10.4196/kjpp.2021.25.6.575
- PubMed https://pubmed.ncbi.nlm.nih.gov/34697268
초록/요약
Composition of the gut microbiota changes with aging and plays an important role in age-associated disease such as metabolic syndrome, cancer, and neurodegeneration. The gut microbiota composition oscillates through the day, and the disruption of their diurnal rhythm results in gut dysbiosis leading to metabolic and immune dysfunctions. It is well documented that circadian rhythm changes with age in several biological functions such as sleep, body temperature, and hormone secretion. However, it is not defined whether the diurnal pattern of gut microbial composition is affected by aging. To evaluate aging effects on the diurnal pattern of the gut microbiome, we evaluated the taxa profiles of cecal contents obtained from young and aged mice of both sexes at daytime and nighttime points by 16S rRNA gene sequencing. At the phylum level, the ratio of Firmicutes to Bacteroidetes and the relative abundances of Verrucomicrobia and Cyanobacteria were increased in aged male mice at night compared with that of young male mice. Meanwhile, the relative abundances of Sutterellaceae, Alloprevotella, Lachnospiraceae UCG-001, and Parasutterella increased in aged female mice at night compared with that of young female mice. The Lachnospiraceae NK4A136 group relative abundance increased in aged mice of both sexes but at opposite time points. These results showed the changes in diurnal patterns of gut microbial composition with aging, which varied depending on the sex of the host. We suggest that disturbed diurnal patterns of the gut microbiome can be a factor for the underlying mechanism of age-associated gut dysbiosis.
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