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Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence

  • 주제(기타) Multidisciplinary Sciences
  • 설명문(일반) [Choi, Eun Jeong; Park, Hyesook] Ewha Womans Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; [Lee, Hye Ah] Ewha Womans Univ, Med Ctr, Clin Trial Ctr, Seoul, South Korea; [Park, Bomi] Chung Ang Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; [Park, Bohyun] Natl Canc Ctr, Natl Canc Control Inst, Goyang, South Korea; [Kim, Hae Soon] Ewha Womans Univ, Coll Med, Dept Pediat, Seoul, South Korea; [Hong, Young Sun] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Park, Hyesook] Ewha Womans Univ, Grad Program Syst Hlth Sci & Engn, Seoul, South Korea
  • 등재 SCIE, SCOPUS
  • OA유형 Green Published, gold
  • 발행기관 NATURE PORTFOLIO
  • 발행년도 2021
  • 총서유형 Journal
  • URI http://www.dcollection.net/handler/ewha/000000190748
  • 본문언어 영어
  • Published As https://doi.org/10.1038/s41598-021-01566-y
  • PubMed https://pubmed.ncbi.nlm.nih.gov/34799615

초록/요약

We explored the association between the trajectory of the continuous metabolic syndrome score (cMetS) in childhood with high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (CIMT), which are known to increase cardiovascular disease risk in adolescence. The trajectory of cMetS in childhood (from 3 to 12 years of age) was identified in 833 children who participated in the Ewha Birth and Growth Study. The associations between cMetS and hs-CRP and CIMT were analyzed in 204 out of 833 children who participated in the follow-up at 13-15 years of age and measured hs-CRP and CIMT. Among the 833 children, three groups were classified: cMetS maintained at a low level (n = 198, 23.77%), middle level (n = 530, 63.63%), and at high levels (n = 105, 12.61%). The group with a stable-high cMetS trajectory showed significantly higher hs-CRP levels, and the statistical significance was maintained after adjusting for covariates. This study found that a consistently high cMetS in childhood was significantly associated with higher hs-CRP levels in adolescents, suggesting that it is necessary to intervene in metabolic risk factors early in life to reduce the risk of cardiovascular disease later in life.

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