Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and F-18-FDG PET/CT
- 주제(기타) Oncology
- 주제(기타) Hematology
- 설명문(일반) [Cho, Hee Jeong; Sohn, Sang Kyun; Moon, Joon Ho] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; [Jung, Sung-Hoon; Lee, Je-Jung] Chonnam Natl Univ Hwasun Hosp, Dept Hematol Oncol, Yeosu, Jeollanam Do, South Korea; [Jung, Sung-Hoon; Min, Jung-Joon; Lee, Je-Jung] Chonnam Natl Univ, Sch Med, Yeosu, Jeollanam Do, South Korea; [Jo, Jae-Cheol; Lee, Yoo Jin] Univ Ulsan, Ulsan Univ Hosp, Dept Hematol & Oncol, Coll Med, Ulsan, South Korea; [Yoon, Sang Eun; Kim, Kihyun] Sungkyunkwan Univ, Dept Med, Samsung Med Ctr, Sch Med, Seoul, South Korea; [Park, Sung-Soo; Min, Chang-Ki] Catholic Univ Korea, Seoul St Marys Hosp, Dept Hematol, Coll Med, Seoul, South Korea; [Kim, Do Young; Shin, Ho-Jin] Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Hematol Oncol, Sch Med, Busan, South Korea; [Mun, Yeung-Chul] Ewha Womans Univ, Dept Hematol Oncol, Med Ctr, Seoul, South Korea; [Yi, Jun Ho] Chung Ang Univ Hosp, Dept Hematol Oncol, Seoul, South Korea; [Kim, Hyo Jung] Hallym Univ, Dept Hematol Oncol, Sacred Heart Hosp, Anyang, South Korea; [Kim, Da Jung; Lee, Ho Sup] Kosin Univ, Gosper Hosp, Dept Hematol Oncol, Busan, South Korea; [Bae, Sung Hwa] Daegu Catholic Univ, Daegu Catholic Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; [Hong, Chae Moon; Jeong, Shin Young] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu, South Korea; [Min, Jung-Joon] Chonnam Natl Univ, Hwasun Hosp, Dept Nucl Med, Yeosu, Jeollanam Do, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 SPRINGERNATURE
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190756
- 본문언어 영어
- Published As https://doi.org/10.1038/s41408-021-00577-2
- PubMed https://pubmed.ncbi.nlm.nih.gov/34853295
초록/요약
In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS) with FL, we analyzed the data of 380 patients with newly diagnosed MM (NDMM) who underwent F-18-fluorodeoxyglucose (F-18-FDG) PET/CT upon diagnosis. The K-adaptive partitioning algorithm was adopted to define subgroups with homogeneous survival. The combined R-ISS with PET/CT classified NDMM patients into four groups: R-ISS/PET stage I (n = 31; R-ISS I with FL <= 3), stage II (n = 156; R-ISS I with FL > 3 and R-ISS II with FL <= 3), stage III (n = 162; R-ISS II with FL > 3 and R-ISS III with FL <= 3), and stage IV (n = 31; R-ISS III with FL > 3). The 2-year overall survival rates for stages I, II, III, and IV were 96.7%, 89.8%, 74.7%, and 50.3%. The 2-year progression-free survival rates were 84.1%, 64.7%, 40.8%, and 17.1%, respectively. The new R-ISS/PET was successfully validated in an external cohort. This new system had a remarkable prognostic power for estimating the survival outcomes of patients with NDMM. This system helps discriminate patients with a good prognosis from those with a poor prognosis more precisely.
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