Clinical impact of left atrial enlargement in Korean patients with atrial fibrillation
- 주제(기타) Multidisciplinary Sciences
- 설명문(일반) [Cho, Min Soo; Cha, Myung-Jin; Kim, Jun] Univ Ulsan, Asan Med Ctr, Div Cardiol, Coll Med, 88 Olymp Ro,43 Gil, Seoul 05505, South Korea; [Park, Hyoung-Seob] Keimyung Univ, Dongsan Hosp, Cardiovasc Ctr, Div Cardiol,Dept Internal Med,Coll Med, Daegu, South Korea; [Lee, So-Ryoung; Choi, Eue-Keun] Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; [Park, Jin-Kyu] Hanyang Univ, Dept Cardiol, Seoul Hosp, Seoul, South Korea; [Kim, Tae-Hoon; Uhm, Jae-Sun; Joung, Boyoung] Yonsei Univ, Severance Cardiovasc Hosp, Dept Internal Med, Div Cardiol,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; [Lee, Jung Myung; Kim, Jin-Bae] Kyung Hee Univ, Kyung Hee Univ Hosp, Dept Internal Med, Div Cardiol, Seoul, South Korea; [Park, Junbeom] Ewha Womans Univ, Sch Med, Dept Cardiol, Seoul, South Korea; [Park, Hyung Wook] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Cardiol, Sch Med, Gwangju, South Korea; [Kang, Ki-Woon] Eulji Univ Hosp, Div Cardiol, Daejeon, South Korea; [Shim, Jaemin] Korea Univ, Dept Internal Med, Div Cardiol, Med Ctr, Seoul, South Korea; [Kim, Changsoo] Yonsei Univ, Coll Med, Inst Human Complex & Syst Sci, Dept Prevent Med, Seoul, South Korea; [Lee, Young Soo] Daegu Catholic Univ, Dept Internal Med, Div Cardiol, Med Ctr, Daegu, South Korea
- 등재 SCIE, SCOPUS
- OA유형 gold, Green Published
- 발행기관 NATURE PORTFOLIO
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190757
- 본문언어 영어
- Published As https://doi.org/10.1038/s41598-021-03266-z
- PubMed https://pubmed.ncbi.nlm.nih.gov/34893667
초록/요약
We sought to evaluate the clinical implication of LAE based on left atrial anterior-posterior (LA AP) dimension or LA volume index (LAVI) in Korean patients with atrial fibrillation (AF). We enrolled 8159 AF patients from the CODE-AF registry. The primary outcome was rate of stroke or systemic embolism (SSE). The prevalence of mild, moderate, and severe LAE by LA AP dimension was 30.6%, 18.5%, and 21.4%, and by LAVI (available in 5808 patients) was 15.7%, 12.5% and 37.8%, respectively. Compared with no or mild LAE, patients with significant LAE (moderate to severe LAE, n = 3258, 39.9%) were associated with a higher rate of SSE (2.5% vs. 1.4%, P = 0.001). Multivariable analysis suggested presence of significant LAE by LA AP dimension was associated with a higher risk of SSE in the overall population (HR 1.57, 95% CI: 1.14-2.17, P = 0.005) and in patients using anticoagulants (n = 5836, HR 1.79, 95% CI: 1.23-2.63, P = 0.002). Patients with significant LAE by LAVI were also at higher risk of SSE (HR 1.58, 95% CI: 1.09-2.29, P = 0.017). In conclusion, significant LAE by LA dimension or LAVI was present in 39.9% and 50.2% of AF patients, respectively, and was associated with a higher rate of SSE.
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