Angiotensin receptor-neprilysin inhibitor in patients with heart failure and chronic kidney disease
- 주제(키워드) Chronic kidney disease , Heart failure , Neprilysin , Renin-angiotensin-aldosterone system
- 주제(기타) Urology & Nephrology
- 설명문(일반) [Cho, In-Jeong] Ewha Womans Univ, Seoul Hosp, Div Cardiol, Dept Internal Med,Coll Med, Seoul, South Korea; [Kang, Seok-Min] Yonsei Univ, Severance Cardiovasc Hosp, Div Cardiol, Dept Internal Med,Coll Med, 50 Yonsei Ro, Seoul 03722, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN SOC NEPHROLOGY
- 발행년도 2021
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000190758
- 본문언어 영어
- Published As https://doi.org/10.23876/j.krcp.21.900
- PubMed https://pubmed.ncbi.nlm.nih.gov/34922429
초록/요약
Despite significant advances in the management of heart failure with reduced ejection fraction (HFrEF), there remains an enormous health problem with high morbidity and mortality over the last few decades. The neprilysin inhibitor enhances the activity of natriuretic peptides, producing vasodilation, natriuresis, and diuresis. Angiotensin receptor blockers inhibit the renin-angiotensin-aldosterone system. Sacubitril/valsartan, a first-in-class angiotensin receptor-neprilysin inhibitor (ARNI), has been shown to improve cardiovascu-lar outcomes in HFrEF and delay the progression of chronic kidney disease (CKD) in patients with HFrEF. The PARADIGM-HF study showed a reduction in diuretic need in the ARNI group. While the use of diuretics is effective in volume control in patients with HFrEF, their use has the potential to adversely affect renal function. Therefore, ARNI therapy could benefit patients with heart failure and CKD by reducing cardiovascular morbidity and mortality and possibly retarding the progression of CKD, although more clinical evi-dence is required in patients with severe CKD and end-stage renal disease.
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