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Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort

  • 주제(키워드) Asthma , Blood Eosinophils , Clinical Burden
  • 주제(기타) Medicine, General & Internal
  • 설명문(일반) [Kim, Mi-Yeong] Inje Univ, Busan Paik Hosp, Dept Internal Med, Coll Med, Busan, South Korea; [Jo, Eun-Jung; Park, Hye-Kyung] Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Internal Med, Coll Med, 179 Gudeok Ro, Busan 49241, South Korea; [Kim, Sujeong] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; [Kim, Min-Hye; Cho, Young-Joo] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; [Jung, Jae-Woo] Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, Joo-Hee] Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Coll Med, Anyang, South Korea; [Moon, Ji-Yong] Hanyang Univ, Guri Hosp, Dept Internal Med, Coll Med, Guri, South Korea; [Kwon, Jae-Woo] Kangwon Natl Univ, Dept Internal Med, Sch Med, Chunchon, South Korea; [Lee, Jae-Hyun; Park, Jung-Won] Yonsei Univ, Dept Internal Med, Div Allergy & Immunol, Coll Med, Seoul, South Korea; [Park, Chan Sun] Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Coll Med, Busan, South Korea; [Jin, Hyun Jung] Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; [Shin, Yoo Seob] Ajou Univ, Dept Allergy & Clin Immunol, Sch Med, Suwon, South Korea; [Kim, Sae-Hoon] Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; [Cho, Sang-Heon] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, Tae-Bum] Univ Ulsan, Asan Med Ctr, Dept Allergy & Clin Immunol, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea
  • 등재 SCIE, SCOPUS, KCI등재
  • OA유형 gold, Green Published
  • 발행기관 KOREAN ACAD MEDICAL SCIENCES
  • 발행년도 2022
  • 총서유형 Journal
  • URI http://www.dcollection.net/handler/ewha/000000190870
  • 본문언어 영어
  • Published As https://doi.org/10.3346/jkms.2022.37.e57
  • PubMed https://pubmed.ncbi.nlm.nih.gov/35191233

초록/요약

Background: Some reports have suggested that the clinical and economic burdens of asthma are associated with blood eosinophil levels. The association between clinical burden and blood eosinophil counts were evaluated in a Korean adult asthma cohort. Methods: Clinical information including blood eosinophil counts that were not affected by systemic corticosteroids were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea database. Clinical burden was defined as 1) asthma control status, 2) medication demand and 3) acute exacerbation (AE) events during 1 consecutive year after enrollment. All patients were divided into atopic and non-atopic asthmatics. The associations between asthma outcomes and the blood eosinophil count were evaluated. Results: In total, 302 patients (124 atopic and 178 non-atopic asthmatics) were enrolled. In all asthmatics, the risk of severe AE was higher in patients with blood eosinophil levels < 100 cells/mu I, than in patients with levels >_ 100 cells/mu I, (odds ratio [OR], 5.406; 95% confidence interval [CI], 1.266-23.078; adjusted P = 0.023). Among atopic asthmatics, the risk of moderate AE was higher in patients with blood eosinophil levels >_ 300 cells/mu I, than in patients with levels < 300 cells/mu L (OR, 3.558; 95% CI, 1.083-11.686; adjusted P = 0.036). Among non-atopic asthmatics, the risk of medication of Global Initiative for Asthma (GINA) steps 4 or 5 was higher in patients with high blood eosinophil levels than in patients with low blood eosinophil levels at cutoffs of 100, 200, 300, 400, and 500 cells/mu L. Conclusion: The baseline blood eosinophil count may predict the future clinical burden of asthma.

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