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Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort

  • 주제(키워드) COPD , non-smoking COPD , KOCOSS database , cohort study , South Korea
  • 주제(기타) Respiratory System
  • 설명문(일반) [Choi, Joon Young] Cathol Univ Korea, Incheon St Marys Hosp, Coll Med, Div Pulm & Crit Care Med Dept Internal Med, Seoul, South Korea; [Kim, Jin Woo] Catholic Univ Korea, Uijeongbu St Marys Hosp, Coll Med, Div Pulmonol & Crit Care Med,Dept Internal Med, Uijongbu, South Korea; [Kim, Yee Hyung] Kyung Hee Univ Hosp, Dept Pulm Allergy & Crit Care Med, Seoul, South Korea; [Yoo, Kwang Ha] Konkuk Univ, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Sch Med, Seoul, South Korea; [Jung, Ki-Suck] Hallym Univ, Sacred Heart Hosp, Div Pulm Allergy & Crit Care Med, Sch Med, Anyang, South Korea; [Lee, Jin Hwa] Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; [Um, Soo-Jung] Dong A Univ, Coll Med, Dong A Univ Hosp, Dept Internal Med,Pulmonol Div, Busan, South Korea; [Lee, Won-Yeon] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Wonju, South Korea; [Park, Dongil] Chungnam Natl Univ, Coll Med, Div Pulmonol, Dept Internal Med, Deajeon, South Korea; [Yoon, Hyoung Kyu] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Pulmonol Crit Care & Sleep Med, Seoul, South Korea
  • 등재 SCIE, SCOPUS
  • OA유형 gold
  • 발행기관 TAYLOR & FRANCIS INC
  • 발행년도 2022
  • 총서유형 Journal
  • URI http://www.dcollection.net/handler/ewha/000000190890
  • 본문언어 영어
  • Published As https://doi.org/10.1080/15412555.2022.2053088
  • PubMed https://pubmed.ncbi.nlm.nih.gov/35392750

초록/요약

Chronic obstructive pulmonary disease (COPD) has been regarded as a disease of smokers, but the prevalence of non-smoking COPD patients have been reported to be considerable. We investigated differences in clinical characteristics between smoking and non-smoking COPD patients. We used data from the Korea COPD Subgroup Study (KOCOSS) database, which is a multicenter cohort that recruits patients from 54 medical centres in Korea. Comprehensive comparisons of smoking and non-smoking COPD patients were performed based on general characteristics, exacerbations, symptom scores, radiological findings, and lung-function tests. Of the 2477 patients included in the study, 8.1% were non-smokers and 91.9% were smokers. Non-smoking COPD patients were more likely to be female and to have a higher body mass index and lower level of education. Non-smoking COPD patients had more comorbidities, including hypertension, osteoporosis, and gastroesophageal reflux disease, and experienced more respiratory and allergic diseases. No significant differences in exacerbation rates, symptom scores, or exercise capacity scores were observed between the two groups. Smoking COPD patients had more emphysematous lung according to the radiological findings, and non-smoking patients had more tuberculosis-destroyed lung and bronchiectasis. Lung-function testing revealed no significant difference in the forced expiratory capacity in 1 sec between the two groups, but smokers had more rapid lung-function decline in the 5 years of follow-up data. We found differences in general characteristics and radiological findings between smoking and non-smoking COPD patients. No significant differences in exacerbation or symptom scores were observed, but decline in lung function was less steep in non-smoking patients. Supplemental data for this article is available online at https://doi.org/10.1080/15412555.2022.2053088 .

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