Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer
- 주제(키워드) Gastrectomy , Ghrelin , Glucagon-like peptide-1 , Stomach neoplasms , Weight loss
- 주제(기타) Gastroenterology & Hepatology; Clinical Neurology
- 설명문(일반) [Jung, Hye-Kyung; Tae, Chung Hyun; Lee, Ko Eun; Moon, Chang Mo; Kim, Seong Eun] Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; [Seoh, Ju Young] Ewha Womans Univ, Dept Microbiol, Coll Med, Seoul, South Korea; [Lee, Joo-Ho] Ewha Womans Univ, Dept Surg, Coll Med, Seoul, South Korea; [Lee, Hye Ah] Ewha Womans Univ, Clin Trial Ctr, Mokdong Hosp, Seoul, South Korea
- 등재 SCIE, SCOPUS, KCI등재
- OA유형 Green Published, gold
- 발행기관 KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY
- 발행년도 2022
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000193059
- 본문언어 영어
- Published As https://doi.org/10.5056/jnm21145
- PubMed https://pubmed.ncbi.nlm.nih.gov/35799234
초록/요약
Background/Aims Post-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims to evaluate the effects of gut regulatory hormones on post-operative weight loss in patients with subtotal gastrectomy for gastric cancer. Methods This prospective study was conducted for 12 months post-surgery in 14 controls and 13 gastrectomy patients who underwent subtotal gastrectomy for gastric cancer. Serum plasma ghrelin, glucagon-like peptide-1, gastric inhibitory peptide-1, peptide YY, insulin, and homeostatic model assessment for insulin resistance responses to a standardized test meal were recorded at multiple time points before and after gastrectomy at 4 and 12 months. Results The mean weight difference between the pre-operative state and the 4-month period was significantly reduced to 6.6 kg (P = 0.032), but significant weight reduction was not observed from 4 months to 12 months. The plasma levels of glucagon-like peptide-1, gastric inhibitory peptide-1, and peptide YY were significantly increased 4 months postoperatively compared to the pre-operative state (all P = 0.035); however, pre-operative levels and relative changes over a period of 0-4 months of hormones were not correlated with body weight changes. Only the pre-operative ghrelin at peak had a negative correlation with changes in weight reduction in the 4 months after surgery (rho = -0.8, P = 0.024). Conclusions Significant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes.
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