A FoxO1-dependent, but NRF2-independent induction of heme oxygenase-1 during muscle atrophy
- 주제(키워드) Nerve injury , MAFbx , MuRF1 , NRF2 , FoxO1
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE BV
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000087090
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.febslet.2013.11.009
초록/요약
Skeletal muscle plays key roles in metabolic homeostasis. Loss of muscle mass, called muscle atrophy exacerbates disease-associated metabolic perturbations. In this study, we characterized the molecular functions and mechanisms underlying regulation of skeletal muscle atrophy induced by denervation. Denervation significantly increased the expression of heme oxygenase-1 (HO-1) and atrogenes in skeletal muscle. Forkhead box protein O1 (FoxO1) drastically increased in atrophied muscle and selectively stimulated HO-1 gene transcription through direct DNA binding. Lack of HO-1 substantially attenuated muscle atrophy, whereas HO-1 overexpression caused muscle damage in vitro and in vivo. Collectively, HO-1 induced by FoxO1 may cause skeletal muscle atrophy. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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