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Enlarged Cavum Septum Pellucidum as a Neurodevelopmental Marker in Adolescent-Onset Opiate Dependence

  • Hwang, Jaeuk (Department of Psychiatry, Soonchunhyang University College of Medicine, Seoul, South Korea) , Kim, Jieun E. (Department of Brain and Cognitive Sciences, Ewha Woman's University Graduate School, Seoul, South Korea) , Kaufman, Marc J. (McLean Imaging Center, McLean Hospital, Belmont, Massachusetts, United States of America) , Renshaw, Perry F. (Department of Psychiatry and The Brain Institute, The University of Utah, Salt Lake City, Utah, United States of America) , Yoon, Sujung (Department of Psychiatry and The Brain Institute, The University of Utah, Salt Lake City, Utah, United States of America, Department of Psychiatry, Catholic University of Korea College of Medicine, Seoul, South Korea) , Yurgelun-Todd, Deborah A. (Department of Psychiatry and The Brain Institute, The University of Utah, Salt Lake City, Utah, United States of America) , Choi, Yera (Interdisciplinary Program in Brain Science, Seoul National University College of Natural Sciences, Seoul, South Korea) , Jun, Chansoo (Ewha Brain Institute & College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Woman's University, Seoul, South Korea) , Lyoo, In Kyoon (류인균, Ewha Brain Institute & College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Woman's University, Seoul, South Korea)
  • PLOS ONE[1932-6203], 2013, v.8 no.10, e78590

초록/요약

Objective: Adolescent-onset exposure to highly addictive substances such as opiates may induce far-reaching deleterious effects on later mental and physical health. However, little is known about the neurodevelopmental basis for adolescent-onset opiate dependence. Here we examined whether having an abnormally large cavum septum pellucidum (CSP), a putative marker of limbic structural maldevelopment, is associated with opiate dependence particularly beginning in adolescence. Method: The overall length of the CSP and the prevalence of abnormal enlargement of the CSP were assessed and compared in 65 opiate-dependent subjects (41 adolescent-onset opiate users and 24 adult-onset opiate users) and 67 healthy subjects. Results: Opiate-dependent subjects showed a greater prevalence of abnormal CSP enlargement relative to healthy subjects (odds ratio [OR]=3.64, p=0.034). The overall CSP length of adolescent-onset opiate-dependent subjects was greater, as compared not only with healthy subjects (F-1,F-104=11.03, p=0.001) but also with those who began opiate use during adulthood (F-1,F-61=4.43, p=0.039). Conclusions: The current findings provide the first evidence that abnormal CSP enlargement, which reflects limbic system dysgenesis of neurodevelopmental origin, may be linked to later development of opiate dependence. In addition, a greater CSP length, which indicates more severe limbic abnormalities, appears to confer higher risk for earlier onset of opiate use.

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