Sasa quelpaertensis Leaf Extract Improves High Fat Diet-Induced Lipid Abnormalities and Regulation of Lipid Metabolism Genes in Rats
- 주제(키워드) gene expression , high-fat diet , lipid metabolism , lipid profile , Sasa quelpaertensis , leaf
- 발행기관 MARY ANN LIEBERT, INC
- 발행년도 2014
- URI http://www.dcollection.net/handler/ewha/000000090742
- 본문언어 영어
- Published As http://dx.doi.org/10.1089/jmf.2013.2916
초록/요약
Sasa quelpaertensis is a bamboo leaf that is only grown on Jeju Island in South Korea. It is used as a bamboo tea that is consumed for therapeutic purposes, particularly for its anti-diabetic, diuretic, and anti-inflammatory effects. This study investigated the effect of S. quelpaertensis leaf extract (SQE) on high fat-induced lipid abnormalities and regulation of lipid metabolism-related gene expressions in rats. SQE supplementation significantly decreased the levels of plasma triglycerides, total cholesterol, and low-density lipoprotein cholesterol as well as the atherogenic index. SQE restored levels of plasma high-density lipoprotein cholesterol, which were lowered by a high fat diet. Plasma and cardiac resistin levels were also significantly decreased by SQE supplementation. In adipose tissue, mRNA levels of CAAT/enhancer-binding protein (C/EBP) were suppressed in the SQE group. SQE supplementation decreased the accumulation of lipid droplets, inflammatory cell infiltrations, levels of triglycerides, and total lipids in the liver and effectively down-regulated expression of sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthetase (FAS), and uncoupling protein 2 (UCP-2). These results suggest that SQE may be a potential treatment for high fat-related disorders by improving lipid profiles and modulating lipid metabolism.
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