Recent progress in development of synthetic biology platforms and metabolic engineering of Corynebacterium glutamicum
- 주제(키워드) Corynebacterium glutamicum , Synthetic biology , Metabolic engineering , Industrial host
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE BV
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000090769
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.jbiotec.2014.03.003
초록/요약
The paradigm of synthetic biology has been evolving, along with relevant engineering, to achieve designed bio-systems. Synthetic biology has reached the point where it is possible to develop microbial strains to produce desired chemicals. Recent advances in this field have promoted metabolic engineering of Corynebacterium glutamicum as an amino-acid producer for use in intelligent microbial-cell factories. Here, we review recent advances that address C. glutamicum as a potential model organism for synthetic biology, and evaluate their industrial applications. Finally, we highlight the perspective of developing C. glutamicum as a step toward advanced microbial-cell factories that could produce valuable chemicals from renewable resources. (c) 2014 Elsevier B.V. All rights reserved.
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