A Preliminary X-ray Study of Murine Tnfaip8/Oxi-alpha
- 주제(키워드) Parkinson's disease , Oxi , oxidative stress , C165S mutant , X-ray crystallography
- 등재 SCIE, SCOPUS
- 발행기관 MDPI AG
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000090898
- 본문언어 영어
- Published As http://dx.doi.org/10.3390/ijms15034523
초록/요약
Tnfaip8/oxidative stress regulated gene- (Oxi-) is a novel protein expressed specifically in brain dopaminergic neurons and its over-expression has been reported to protect dopaminergic cells against OS-induced cell death. In this study, murine C165S mutant Tnfaip8/Oxi- has been crystallized and X-ray data have been collected to 1.8 angstrom using synchrotron radiation. The crystal belonged to the primitive orthorhombic space group P2(1)2(1)2, with unit-cell parameters a = 66.9, b = 72.3, c = 93.5 angstrom. A full structural determination is under way in order to provide insights into the structure-function relationships of this protein.
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