Autologous Stem Cell Transplantation for Expansion of Remnant Liver Volume with Extensive Hepatectomy
- 주제(키워드) Autologous stem cell transplantation , Liver volume , Extensive hepatectomy , Regeneration , Stem cell
- 설명문(URI) http://www.ncbi.nlm.nih.gov/pubmed/24895813
- 등재 SCIE, SCOPUS
- 발행기관 H G E UPDATE MEDICAL PUBLISHING S A
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000091020
- 본문언어 영어
초록/요약
Background/Aims: The plasticity of bone marrow stem cells has been confirmed to self-renew and transdifferentiate into hepatocytes. Thus, we performed autologous stem cell transplantation for rapid liver regeneration with extensive hepatectomy in hepatocellular cancer patients. Methodology: With in formed consent, patients aged 20 to 75 who needed large extensive hepatectomy due to hepatocellular carcinoma were randomly divided into three groups: control, mononuclear cells (MNCs), and CD34+ cells, based on infused cell type. After portal vein embolization (PVE), mobilized MNCs or CD34+ cells were returned to the patient via the portal vein on mobilization day without manipulation. Liver volume, liver function, Clinical score and Indocyanine green R15 (ICG-R15) were compared before and after PVE. Results: Total bilirubin, albumin, and clinical score showed significant improvement (p < 0.05) 1 week post-infusion, with no significant difference between MNC and CD34+ cell groups. Four patients (control, 1; MNC, 1; CD34+, 2) started at over 18% ICG-R15 but can be overturned after PVE. Daily hepatic volume growth (mL/day) was 2.5 for MNC and 4.9 for CD34+ groups, resulting in significant increase over controls (1.1; p < 0.05). We found no correlation between the number of applied CD34+ cells and daily gains in left lateral lobe volume. Conclusions: Improvements in liver volume, liver function, clinical score and ICG-R15 suggest that autologous stem cell transplantation is a promising method for liver regeneration.
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