Combination of transcranial direct current stimulation and methylphenidate in subacute stroke
- 주제(키워드) tDCS , Methylphenidate , TMS , Cortical excitability
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER IRELAND LTD
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000091124
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.neulet.2014.03.011
초록/요약
Noninvasive transcranial direct current stimulation (tDCS) and methylphenidate (MP) are associated with motor recovery after stroke. Based on the potentially complementary mechanisms of these interventions, we examined whether there is an interactive effect between MP and tDCS. In this preliminary study, we randomized subacute stroke subjects to receive tDCS alone, MP alone or combination of tDCS and MP. A blinded rater measured safety, hand function, and cortical excitability before and after treatment. None of the treatments caused any major or severe adverse effects or induced significant differences in cortical excitability. Analysis of variance of gain score, as measured by Purdue pegboard test, showed a significant between-group difference (F-(2,F-6) = 12.167, p = 0.008). Post hoc analysis showed that the combination treatment effected greater Purdue pegboard gain scores than tDCS alone (p = 0.017) or MP alone (p = 0.01). Our preliminary data with nine subjects shows an interesting dissociation between motor function improvement and lack of motor corticospinal plasticity changes as indexed by transcranial magnetic stimulation in subacute stroke subjects. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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