Tripartite Motif-Containing Protein 30 Modulates TCR-Activated Proliferation and Effector Functions in CD4(+) T Cells
- 등재 SCIE, SCOPUS
- 발행기관 PUBLIC LIBRARY SCIENCE
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000091265
- 본문언어 영어
- Published As http://dx.doi.org/10.1371/journal.pone.0095805
초록/요약
To avoid excessive activation, immune signals are tightly controlled by diverse inhibitory proteins. TRIM30, a tripartite motif (TRIM)-containing protein is one of such inhibitors known to function in macrophages. To define the roles of TRIM30, we generated Trim30 knockout (Trim30(-/-)) mice. Trim30 deletion caused no major developmental defects in any organs, nor showed any discernable defect in the activation of macrophages. But, Trim30(-/-) mice showed increased CD4/CD8 ratio when aged and Trim30(-/-) CD4(+) T cells exhibited an abnormal response upon TCR activation, in particular in the absence of a costimulatory signal. Adoptive transfer of wild-type and Trim30(-/-) CD4(+) T cells together into lymphopenic hosts confirmed higher proliferation of the Trim30(-/-) CD4(+) T cells in vivo. Despite the enhanced proliferation, Trim30(-/-) T cells showed decreased levels of NF-kappa B activation and IL-2 production compared to wild-type cells. These results indicate a distinct requirement for TRIM30 in modulation of NF-kappa B activation and cell proliferation induced by TCR stimulation.
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