Activation of YAP1 Is Associated with Poor Prognosis and Response to Taxanes in Ovarian Cancer
- 주제(키워드) DNA microarrays , ovarian cancer , prognosis , taxane , YAP1
- 설명문(URI) http://ar.iiarjournals.org/content/34/2/811.abstract?sid=3f91b68f-350c-4987-847f-2699a94224ca
- 등재 SCIE, SCOPUS
- 발행기관 INT INST ANTICANCER RESEARCH
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000091270
- 본문언어 영어
초록/요약
Aim: We aimed to investigate the clinical significance of the activation of Yes-Associated Protein 1 (YAP1), a key downstream effector of Hippo tumor-suppressor pathway, in ovarian cancer. Materials and Methods: A gene expression signature reflecting activation of YAP1 was developed from gene expression data of 267 samples from patients with ovarian cancer. A refined ovarian cancer YAP1 signature was validated in an independent ovarian cancer cohort (n=185). Associations between the YAP1 signature and prognosis were assessed using Kaplan-Meier plots, the log-rank test, and a Cox proportional hazards model. Results: We identified a 612-gene expression signature reflecting YAP1 activation in ovarian cancer. In multivariate analysis, the signature was an independent predictor of overall survival (hazard ratio=1.66; 95% confidence interval=1.1 to 2.53; p=0.01). In subset analysis, the signature identified patients likely to benefit from taxane-based adjuvant chemotherapy. Conclusion: Activation of YAP1 is significantly associated with prognosis and the YAP1 signature can predict response to taxane-based adjuvant chemotherapy in patients with ovarian cancer.
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