Crowding-induced structural alterations of random-loop chromosome model
- 등재 SCIE, SCOPUS
- 발행기관 American Physical Society
- 발행년도 2011
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000092230
- 본문언어 영어
- Published As http://dx.doi.org/10.1103/PhysRevLett.106.168102
초록/요약
We investigate structural alterations of random-loop polymers due to changes in the crowding condition, as a model to study environmental effects on the structure of chromosome subcompartments. The polymer structure is changed in a nonmonotonic fashion with an increasing density of crowders: condensed at small volume fractions; decondensed at high crowding volume fractions. The nonmonotonic behavior is a manifestation of the nontrivial distance dependence of the depletion interactions. We also show that crowding-induced structural alterations affect the access of binding proteins to the surface of polymer segments and are distinguished from structural changes due to the increased number of specific polymer loops. © 2011 American Physical Society.
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