Cross metathesis assisted solid-phase synthesis of glycopeptoids
- 등재 SCIE, SCOPUS
- 발행기관 American Chemical Society
- 발행년도 2012
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000093771
- 본문언어 영어
- Published As http://dx.doi.org/10.1021/ol300808c
초록/요약
A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good yields. This systematic solid-phase CM study can provide facile access to the molecular sources of glycopeptidomimetics and postchemical modifications on various molecular scaffolds. © 2012 American Chemical Society.
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