Synthesis and physicochemical properties of new tripodal amphiphiles bearing fatty acids as a hydrophobic group
- 주제(키워드) Cyclotriphosphazene , Drug delivery , Fatty acid , Micelle , Tripodal amphiphile
- 등재 SCIE, SCOPUS
- 발행기관 Pergamon Press Ltd.
- 발행년도 2013
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000094723
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.bmcl.2013.01.052
초록/요약
Saturated fatty acids (FA) were grafted using tyrosine as a spacer group to the cyclotriphosphazene ring along with equimolar hydrophilic methoxy poly(ethylene glycol) (MPEG) in cis-nongeminal way. Seven new cyclotriphosphazene amphiphiles were prepared from combinations of hydrophilic MPEGs with different molecular weights of 350, 550, 750 and 1000 and four different fatty acids of different hydrophobicity including lauric, myristic, palmitic and stearic acids. These steric amphiphiles bearing fatty acids as a hydrophobic group were found to form more stable micelles with very low critical micelle concentrations (CMC) (2.95-7.80 mg/L) compared with oligopeptide analogues, and their highly hydrophobic core environment is unique and potentially useful for various biomedical applications. © 2013 Elsevier Ltd. All rights reserved.
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