Down-regulation of Sox11 is required for efficient osteogenic differentiation of adipose-derived stem cells
- 주제(키워드) transcription factor Sox11 , adipocyte , adipose derived stem cell , animal cell , article , bone development , cell differentiation , controlled study , down regulation , gene cluster , gene expression profiling , in vitro study , male , microarray analysis , mouse , nonhuman , osteoblast , osteogenic differentiation , protein analysis , protein expression , protein function
- 등재 SCOPUS
- 발행기관 Korean Society for Molecular and Cellular Biology
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000096525
- 본문언어 영어
- Published As http://dx.doi.org/10.14348/molcells.2014.0021
초록/요약
Adipose-derived stem cells represent a type of mesenchymal stem cells with the attendant capacity to self-renew and differentiate into multiple cell lineages. We have performed a microarray-based gene expression profiling of osteogenic differentiation and found that the transcription factor Sox11 is down-regulated during the process. Functional assays demonstrate that down-regulation of Sox11 is required for an efficient differentiation. Furthermore, results from forced expression of constitutively-active and dominant-negative derivatives of Sox11 indicate that Sox11 functions as a transcriptional activator in inhibiting osteogenesis. Sox11 thus represents a novel regulator of osteogenesis whose expression and activity can be potentially manipulated for controlled differentiation.
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