Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.
- 주제(키워드) Sponge , Ircinia sp. , Sesquiterpenoids , PPARδ , Obesity
- 등재 SCIE, SCOPUS
- 발행기관 Elsevier BV
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000097802
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.tetlet.2014.07.019
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2–5) as well as two isolation artifacts (6–7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPARδ agonistic activities, with EC50 values of 18 and 30 μg/mL, respectively.
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