Synthesis and Biological Evaluation of 1-Heteroarylmethyl 1,4-Diazepanes Derivatives as Potential T-type Calcium Channel Blockers
- 주제(키워드) T-type calcium channel blockers , 1 , 4-Diazepanes , Heteroaromatic compounds , FDSS6000 assay , Patch-clamp assay
- 발행기관 KOREAN CHEMICAL SOC
- 발행년도 2011
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000098531
- 본문언어 영어
- Published As http://dx.doi.org/10.5012/bkcs.2011.32.8.3063
초록/요약
The synthesis and biological evaluation of 1-heteroarylmethyl 1,4-diazepane derivatives as potential T-type calcium channel blockers is described. In this study, we have identified the compound 211 exhibiting the most potent T-type calcium channel blocking activity with IC(50) value of 0.20 mu M, which is superior to that of mibefradil.
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