Protein kinase A regulates the osteogenic activity of Osterix
- 주제(키워드) OSTEOBLAST DIFFERENTIATION , OSTERIX , PROTEIN KINASE A , PROTEIN STABILITY , TRANSCRIPTIONAL ACTIVITY
- 등재 SCIE, SCOPUS
- 발행기관 Wiley-Liss Inc.
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000098692
- 본문언어 영어
- Published As http://dx.doi.org/10.1002/jcb.24851
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Osterix belongs to the SP gene family and is a core transcription factor responsible for osteoblast differentiation and bone formation. Activation of protein kinase A (PKA), a serine/threonine kinase, is essential for controlling bone formation and BMP-induced osteoblast differentiation. However, the relationship between Osterix and PKA is still unclear. In this report, we investigated the precise role of the PKA pathway in regulating Osterix during osteoblast differentiation. We found that PKA increased the protein level of Osterix; PKA phosphorylated Osterix, increased protein stability, and enhanced the transcriptional activity of Osterix. These results suggest that Osterix is a novel target of PKA, and PKA modulates osteoblast differentiation partially through the regulation of Osterix. © 2014 Wiley Periodicals, Inc.
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