Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics
- 등재 SCIE, SCOPUS
- 발행기관 American Society for Biochemistry and Molecular Biology Inc.
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000098694
- 본문언어 영어
- Published As http://dx.doi.org/10.1074/jbc.M113.532358
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Background: Ninjurin1 promotes leukocyte trafficking during inflammation through homotypic binding. Results: Changes in Ninjurin1 expression in macrophages regulate protrusive membrane dynamics, motility, and in turn transendothelial migration. Conclusion: The pro-migratory function and binding activity of Ninjurin1 are important for modulating immune responses during inflammation. Significance: This study provides additional insights into the understanding of Ninjurin1-mediated inflammation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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