Optimal dose of dexmedetomidine for attenuating cardiovascular response during emergence in patients undergoing total laparoscopic hysterectomy
- 주제(키워드) Blood pressure , dexmedetomidine , emergence , heart rate , tracheal extubation
- 등재 SCIE, SCOPUS
- 발행기관 SAGE PUBLICATIONS LTD
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000109687
- 본문언어 영어
- Published As http://dx.doi.org/10.1177/0300060514531925
초록/요약
Objective: To investigate the optimal dose of dexmedetomidine for attenuating the haemodynamic response during emergence from anaesthesia. Methods: Patients undergoing laparoscopic total hysterectomy were randomly allocated to receive 0.9% normal saline (control group) or dexmedetomidine (0.5 mu g/kg, 0.75 mu g/kg or 1.0 mu g/kg 30 min) before extubation. Heart rate, systolic and diastolic arterial pressure and extubation time were measured before drug administration, immediately after the end of drug administration, 10 min after the end of drug administration, immediately after extubation and 5 min after extubation. Results: A total of 120 patients were included in the study (30 per group). Systolic and diastolic arterial pressure and heart rate after drug administration were significantly lower in all three dexmedetomidine groups compared with controls. Extubation times in the 0.75 and 1.0 mu g/kg dexmedetomidine groups were significantly longer than in the control group. Conclusion: Intravenous infusion of 0.5 mu g/kg dexmedetomidine 30 min before the end of surgery attenuated the haemodynamic responses during emergence without prolonging the extubation time. Dexmedetomidine doses higher than 0.5 mu g/kg did not exert additional positive effects on cardiovascular responses, but did significantly prolong the extubation time.
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