Synthesis of 3,4,5-Trisubstituted Isoxazoles through Gold-Catalyzed Cascade Cyclization Oxidative Alkynylation and Cyclization-Fluorination of 2-Alkynone O-Methyloximes
- 주제(키워드) Gold , Isoxazole , O-Methyloxime , Cross-coupling , Alkyne
- 발행기관 KOREAN CHEMICAL SOC
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000109695
- 본문언어 영어
- Published As http://dx.doi.org/10.5012/bkcs.2014.35.9.2635
초록/요약
Gold-catalyzed tandem cyclization oxidative alkynylation and cyclization-fluorination reactions of 2-alkynone O-methyloximes are described. The reactions proceed smoothly at room temperature in the presence of 10 mol % of (PPh3)AuNTf2, 2.5 equivalents of selectfluor, and 2 equivalents of K3PO4. 2-Alkynone O-methyloximes undergo intramolecular oxyauration/cyclization and ensuing oxidative cross-coupling and fluorination process to afford the corresponding 3,4,5-trisubstituted isoxazoles in a cascade manner.
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