Pharmacokinetic evaluation of formulated levodopa methyl ester nasal delivery systems
- 주제(키워드) Levodopa methyl ester , Pharmacokinetics , Nasal delivery
- 등재 SCIE, SCOPUS
- 발행기관 SPRINGER FRANCE
- 발행년도 2014
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000112994
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s13318-013-0171-8
초록/요약
The objective of this study was to investigate the pharmacokinetic characteristics of levodopa (l-dopa) from nasal powder formulations using highly water-soluble levodopa methyl ester hydrochloride (LDME). In vivo pharmacokinetic studies were carried out with formulated LDME nasal powders. After oral and intravenous administration of l-dopa and carbidopa and intranasal administration LDME to the rat, l-dopa concentrations were determined in plasma and the brain using high-performance liquid chromatography. The absolute bioavailabilities of nasal preparations with and without Carbopol were 82.4 and 66.7 %, respectively, which were much higher than that of oral delivery (16.2 %). The drug-targeting efficiencies [area under the curve (AUC) in brain/AUC in plasma] of l-dopa in the nasal formulations (0.98-1.08) were much higher than that of oral preparation (0.69). These results suggest that LDME nasal powder formulations would be useful delivery systems of l-dopa to the brain.
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