Protective effects of Akebia quinata fruit extract on acute alcohol-induced hepatotoxicity in mice
- 주제(키워드) Acute alcohol-induced liver injury , Akebia quinata , Glutathione , NADPH oxidase 4 , Tumor necrosis factor alpha
- 등재 KCI등재, SCOPUS
- 발행기관 Korean Society of Food Science and Technology
- 발행년도 2014
- URI http://www.dcollection.net/handler/ewha/000000113189
- 본문언어 한국어
- Published As http://dx.doi.org/10.9721/KJFST.2014.46.5.622
초록/요약
We studied the effects of Akebia quinata fruit extract (AQ) on acute alcohol-induced hepatotoxicity in mice. AQ (30-1,000 mg/kg body weight (BW) per day) was orally administered to the study group, once daily for 1 week. On the last day of AQ treatment, ethanol (6 mg/kg BW) was orally administered to induce acute liver injury. The AQ-treated group showed significantly lower levels of alanine aminotransferase and aspartate aminotransferase, compared to the only ethanol-treated group (ETG). The glutathione level in the AQ-treated group elevated up to 20.6%, compared to that observed in the ETG. The mRNA expression of glutathione synthetic enzymes was also higher in the AQ-treated group, compared to the ETG. The AQ-treated group also exhibited lower levels of expression of NADPH oxidase 4 and tumor necrosis factor alpha mRNA. Thus, these results show that AQ treatment can be a potential method to reduce oxidative stress and inflammation in ethanol-treated mouse liver and also that AQ can be a useful therapeutic agent for acute alcohol-induced hepatotoxicity.
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