Selective zinc sensor based on pyrazoles and quinoline used to image cells
- 주제(키워드) Zinc sensor , Quinoline , Visible absorption , Cell imaging , Fluorescence , Selective
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCI LTD
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000114281
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.dyepig.2014.10.006
초록/요약
The synthesis, Zn2+ binding, crystal structure, and cell imaging studies of a new pyrazole amine quinoline receptor with a flexible binding pocket are described. Upon coordination to Zn2+, the absorption of the receptor increases at 364 nm and it fluoresces at 500 nm. The fluorescence response to Zn2+ is selective for Zn2+ and does not occur with other metal ions, not even Cd2+. In solution, the receptor forms 1:1 complexes with Zn2+, but in the solid-state two Zn2+ ions coordinate to the receptor. The aqueous solubility of the receptor allows for imaging of Zn2+ in living cells. Cells exposed to receptor and Zn2+ fluoresce when excited with visible light. (C) 2014 Elsevier Ltd. All rights reserved.
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