Cytotoxic 5 alpha,8 alpha-epidioxy sterols from the marine sponge Monanchora sp.
- 주제(키워드) 5 alpha , 8 alpha-epidioxy sterol , Monanchora sp. , Cytotoxicity , Pancreatic cancer , Renal cancer , Colorectal cancer
- 등재 SCIE, KCI등재, SCOPUS
- 발행기관 PHARMACEUTICAL SOC KOREA
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000114385
- 본문언어 영어
- Published As http://dx.doi.org/10.1007/s12272-014-0480-8
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
Three new sterols, 5 alpha,8 alpha-epidioxy-24-norcholesta-6,9(11),22-trien-3 beta-ol (1), 5 alpha,8 alpha-epidioxy-cholesta-6,9(11),24-trien-3 beta-ol (2), and 5 alpha,8 alpha-epidioxy-cholesta-6,23-dien-3 beta,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.
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