3,4,5-Trimethoxycinnamin acid ameliorates restraint stress-induced anxiety and depression
- 주제(키워드) TMCA , Anxiety , Depression , Delta FosB , SC1
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER IRELAND LTD
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000114457
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.neulet.2014.11.016
초록/요약
The present study investigated whether 3,4,5-trimethoxycinnamic acid (TMCA) treatment ameliorated restraint stress-provoked anxiety- and depression-like behaviors in mice. Fourteen consecutive days of restraint stress produced anxiety- and depression-like behaviors, including reduced time and frequency in the open arms of the elevated plus maze (EPM), as well as enhanced immobility times in the forced swim test (FST). However, TMCA (50 mg/kg) treatment ameliorated this effect; mice showed increased time and frequency of visits in the open arms of the EPM and showed reduced immobility in the FST. In parallel with the behavioral data, long-lasting stimulation of Delta FosB in the nucleus accumbens shell subregion was exhibited in response to TMCA. Furthermore, a reduction in expression of SC1, a target of Delta FosB, in the nucleus accumbens of mice subjected to restraint stress was significantly reversed by TMCA (50 mg/kg) treatment. Collectively, these results suggest that TMCA treatment might provide a therapeutic strategy for treatment of anxiety and depression. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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