Hippocampal volume and shape in pure subcortical vascular dementia
- 주제(키워드) Alzheimer's disease , Vascular dementia , Hippocampus , PiB-PET
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE INC
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000114486
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.neurobiolaging.2014.08.009
초록/요약
The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative C-11-Pittsburg compound-B (PiB(-)) positron emission tomography and to compare hippocampal volume and shape between PiB-SVaD and PiB positive (PiB(-)) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB(-)SVaD, 34 with PiB(+) AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB-SVaD was significantly smaller than NC but larger than that of PiB(+) AD (NC > PiB-SVaD > PiB(+) AD). Both PiB(-)SVaD and PiB(+) AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB(-)SVaD and PiB(+) AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB(-) AD. PiB(+) SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes. (C) 2015 Elsevier Inc. All rights reserved.
more