Visualization of endogenous and exogenous hydrogen peroxide using a lysosome-targetable fluorescent probe
- 등재 SCIE, SCOPUS
- 발행기관 Nature Publishing Group
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000114545
- 본문언어 영어
- Published As http://dx.doi.org/10.1038/srep08488
초록/요약
Reactive oxygen species (ROS) play crucial roles in diverse physiological processes; therefore, the efficient detection of ROS is very crucial. In this study, we report a boronate-based hydrogen peroxide (H2O2) probe having naphthalimide fluorophore. This probe also contained a morpholine moiety as a directing group for lysosome. The recognition property indicated that the probe exhibited high selectivity towards H2O2 not only in the solution but also in the living cells. Furthermore, it was used to monitor the level of endogenous and exogenous H2O2. These results support that the probe can function as an efficient indicator to detect H2O2.
more