Association between the APOB rs1469513 polymorphism and obesity is modified by dietary fat intake in Koreans
- 주제(키워드) APOB , Gene-diet interaction , Lipid profile , Obesity , rs1469513
- 등재 SCIE, SCOPUS
- 발행기관 ELSEVIER SCIENCE INC
- 발행년도 2015
- URI http://www.dcollection.net/handler/ewha/000000114797
- 본문언어 영어
- Published As http://dx.doi.org/10.1016/j.nut.2014.10.007
초록/요약
Objective: The apolipoprotein B (APOB) gene has been reported to be a candidate gene for individual susceptibility to dyslipidemia and obesity. The aim of this study was to investigate the effect of the APOB rs1469513 polymorphism on plasma lipid profiles and obesity-related phenotypes, together with their modulation by dietary intake in Korean individuals. Methods: We analyzed the plasma lipid profiles, obesity-related phenotypes, and dietary intake of 6470 Korean aged 40 to 59 y from the KoGES (Korean Genome Epidemiology Study) database. The effects of APOB rs1469513 on traits, the interaction of APOB rs1469513 and dietary intake on traits were analyzed. Results: Plasma levels of total cholesterol (P = 0.001) and low-density lipoprotein cholesterol (P = 0.010), body weight (P = 0.048), and body mass index (P = 0.029) were significantly different in carriers of the A allele and minor G allele of APOB rs1469513. Among individuals whose fat intake was above the median, the difference for the body mass index across genotypes is 1.14% (AA 24.66 kg/m(2) versus AG+GG 24.94 kg/m(2), P = 0.004) and carriers of the minor G allele had increased odds of being obese (Odds ratios, 1.31; 95% confidence interval, 1.09-1.57; P = 0.004) compared with homozygotes for the A allele. Conclusions: Our findings support a significant association between the APOB rs1469513 variant, plasma lipid profiles, and obesity-related phenotypes. This association has the potential to be modified by dietary fat intake. These results may offer proof that the differences between normal weight and overweight/obese individuals might partly result from different SNPs. (C) 2015 Elsevier Inc. All rights reserved.
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