Short-term Treatment of Daumone Improves Hepatic Inflammation in Aged Mice
- 주제(키워드) Aging , Hep G2 cells , Inflammation , Liver , Pheromones
- 등재 SCIE, KCI등재, SCOPUS
- 발행기관 KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000115639
- 본문언어 영어
- Published As http://dx.doi.org/10.4196/kjpp.2015.19.3.269
초록/요약
Chronic inflammation has been proposed as one of the main molecular mechanisms of aging and age-related diseases. Although evidence in humans is limited, short-term calorie restriction (CR) has been shown to have anti-inflammatory effects in aged experimental animals. We reported on the long-term treatment of daumone, a synthetic pheromone secreted by Caenorhabditis elegans in an energy deficient environment, extends the life-span and attenuates liver injury in aged mice. The present study examined whether late onset short-term treatment of daumone exerts anti-inflammatory effects in the livers of aged mice. Daumone was administered orally at doses of 2 or 20 mg/kg/day for 5 weeks to 24-month-old male C57BL/6J mice. Increased liver macrophage infiltration and gene expression of proinflammatory cytokines in aged mice were significantly attenuated by daumone treatment, suggesting that short-term oral administration of daumone may have hepatoprotective effects. Daumone also dose-dependently suppressed tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor-kappa B (NF-kappa B) phosphorylation in HepG2 cells. The present data demonstrated that short-term treatment of daumone has anti-inflammatory effects in aged mouse livers possibly through suppression of NF-kappa B signaling and suggest that daumone may become a lead compound targeting aging and age-associated diseases.
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