Chemical genetics approach reveals importance of cAMP and MAP kinase signaling to lipid and carotenoid biosynthesis in microalgae
- 주제(키워드) CAMP signaling , Carotenoid biosynthesis , Lipid biosynthesis , MAP kinase , Microalgal signaling pathways
- 등재 SCIE, KCI등재, SCOPUS
- 발행기관 Korean Society for Microbiolog and Biotechnology
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000115843
- 본문언어 영어
- Published As http://dx.doi.org/10.4014/jmb.1408.08035
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
In this study, we attempted to understand signaling pathways behind lipid biosynthesis by employing a chemical genetics approach based on small molecule inhibitors. Specific signaling inhibitors of MAP kinase or modulators of cAMP signaling were selected to evaluate the functional roles of each of the key signaling pathways in three different microalgal species: Chlamydomonas reinhardtii, Chlorella vulgaris, and Haematococcus pluvialis. Our results clearly indicate that cAMP signaling pathways are indeed positively associated with microalgal lipid biosynthesis. In contrast, MAP kinase pathways in three microalgal species are all negatively implicated in both lipid and carotenoid biosynthesis. © 2015 by The Korean Society for Microbiology and Biotechnology.
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