Novel germline mutation of BRCA1 gene in a 56-Year-Old woman with breast cancer, ovarian cancer, and diffuse large B-Cell Lymphoma
- 주제(키워드) BRCA1 gene , Breast neoplasms , Lymphoma , Ovarian neoplasms
- 등재 SCIE, KCI등재, SCOPUS
- 발행기관 Korean Cancer Association
- 발행년도 2015
- 총서유형 Journal
- URI http://www.dcollection.net/handler/ewha/000000118417
- 본문언어 영어
- Published As http://dx.doi.org/10.4143/crt.2013.151
- 저작권 이화여자대학교 논문은 저작권에 의해 보호받습니다.
초록/요약
We report a case of a 56-year-old woman with breast cancer, ovarian cancer, and diffuse large B-cell lymphoma with a BRCA1 gene mutation. Evidence is mounting that there is a large increase in the risk for hematologic malignancies among patients with genetic changes in the BRCA pathways. The genomic analysis demonstrated a frameshift mutation in the BRCA1 gene: 277_279delinsCC (Phe93fs). It is a novel BRCA1 mutation that has never been reported, and caused malignant lymphoma as well as breast and ovarian cancer. © 2015 by the Korean Cancer Association.
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